Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack on an hidden munitions depot in Syria used by the IS group, as stated by the British defence ministry.
The site, located using intelligence, was thought to be housing weapons and explosive materials, the release indicated, and was situated in mountains just to the north of Palmyra in central Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a several approach shafts down to the site... preliminary assessments suggest the target was engaged successfully," officials stated.
There was no evidence of any civilian impact in the strike late on Saturday and every plane involved made a safe return, the MoD added.
The British jets were backed up by a Voyager refuelling tanker.
Daesh - also known as the so-called Islamic State - imposed militant control over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike underscores British leadership, and commitment to work closely with allied nations, to eradicate any resurgence of Daesh and their violent and radical beliefs in the Middle East," UK Defence Secretary the Defence Secretary stated.
RAF aircraft have performed surveillance missions over Syrian airspace to "prevent any attempted resurgence" of the group after its defeat at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I extend gratitude to the personnel of our armed forces participating in this mission for their skill and their courage," he said. "They were among thousands of British troops stationed over the festive period. This action, to eliminate militants who endanger our safety, highlights how our armed forces are ready to step up, all year round, protecting the UK at home and influential overseas."
In December, the American forces executed what it called a "massive strike" targeting Islamic State objectives in the country, after an assault resulted in the deaths of two US troops and a civilian linguist in Palmyra.
The UN estimates IS still maintains between 5,000 and 7,000 militants in Iraq and Syria.